Ok first of all I should confirm it is the saunders type diaphragm valve.
The whole question arose during a HAZOP. We were looking at the 'more pressure' possibilities in a line pumping a fluid (nonafluorobutane). It was decided more pressure could occur if the stretch of line was valved off and the liquid then allowed to warm up - thermal expansion causing a hydraulic pressure that would rupture the line. I was surprised to find this had happened a number of times in the past.
To militate against this problem it was decided to replace the ball valves with diaphragm valves. The diaphragm would represent the weak point in the line and would lift, allowing enough liquid through the valve body to lower the pressure.
I have numerous issues with this - first I dont think the relief pressure of the valve can be guaranteed (insofar as a manufacturer wont give us certification) so it shouldnt be used as a safety device. Therefore it's use as a mitigant in the HAZOP was invalid.
Secondly - no thought was made to the downstream relief line. It would just blow out of the valve (creating another hazard).
Im a junior engineer and feel a bit awkward telling the client they're wrong

The question was really if anyone knew of any legislation or guidance on how these things should be used. Perhaps someone could proposed an alternate method??
Thanks for the help guys.