Based on my experience about the Crude Distillation Unit, the crude it pre-heated, desalted, then again heated (in heat-ex or fired heater) before it is routed to the distillation column for separation.
Since, the crude is desalted, the pressure of the system is above the vapour pressure of the liquid by at least 2 bar i.e. there is no chance of two phase till the outlet of the desalter.
I would rather have liquid crude to the maximum extent possible till it is feed to the column, simply because it is easy to carry out single phase liquid hydraulics. Also, the piping support required for the single phase is less stringent than the two phase flow.
Now coming to your point, I would rather pump the crude through the heater in liquid phase instead of separating the gas-liquid, then heating the liquid and again mixing it with the gas.
Is your system already existing one, or you are preparing FEED for the system ?
Maybe a little more information would be helpful.