What is the function of the tower and what are you specifying? Application can make a difference, and be careful you are not specifying something that cannot be achieved.
For a reboiled absorber (stripper) with one feed you should only have one degree of freedom, so only one spec to play with. Typically operating pressure is defined and estimates for top and bottom temperatures can be input as well. For this application I usually specify one of: reboiler duty, bottom temperature, bottom liquid vapour pressure or component fraction (these are not the only options, just the ones I use most often). Eg, for a condensate stabilizer tower I typically specify the ethane content in the bottom liquid stream, or the RVP of the stabilized product.
Cheers,