as said it depends from specific application,
in some cases a software can help (I use mainly Prode + Excel but I presume most simulators have equivalent features),
but it depends, some cases :
for liquid-liquid miscibility etc. you solve phase equilibria
for coalescence probably you mean simulation of a coalescer, I have created (Excel) a specific model (don't know if Aspen has buil-in model)
for chelation you can define (for example) equilibrium cosntants in reaction
for coagulation (for example in water treatment) you solve a solid precipitation (multi phase equilibria)
for emulsions, foaming etc. better to define specific models (or applications),
for a short introduction
dragon.unideb.hu/~kolloid/colloid/lectures/pharmacy/lecture09.pdf
and so on...