1 reply to this topic

[process equipment]

Dear all,

Alhough crystallization is very complex to understand because it's still an unkbown area it is used in so many industrial plants. But can anyone tell me why seeding is so important in crystallization and why crystallization process will become more important and interest in the future ???

I would like to hear from you all..because i'm working on a crystallization project !!

Cheers

PE

[PatrickL]

Seeding is important to help control your crystal size distribution. If you are running a continuous crystallizer and you don't seed - it can take forever to feed all those little nucleates up to a decent size (but there are tricks....)

Seeding is also important because of polymorphs - you can actually get the wrong stuff if the wrong polymorph starts crystallizing out first.

Crystallization is getting more important (opinion here) because more and more pharmaceutical processes and organic processes are starting to use crystallization as a means of separation / purification. Crystallization can be an excellent low energy separation/purification method.